Rescuing Stalled or Damaged Replication Forks

The stalled replication fork can collapse if these regulatory proteins fail to stabilize it. ... When this occurs, reassembly of the fork is initiated in order to ...

由 H Liao 著作 · 2018 · 被引用 178 次 — Stalled replication forks are a major source of genome instability in proliferating cells, which need to be stabilized and restarted to promote cell survival.

2021年2月23日 — In the laboratory, replication forks can be stalled by the action of hydroxyurea. Hydroxyurea depletes the cellular pools of dNTPs, which are ...

It is now clear that replication forks stall frequently as a result of encounters between the replication machinery and template damage, slow-moving or paused ...

Two main activities happen at the fork: DNA unwinding and DNA synthesis. The RF unwinds the unreplicated DNA ahead of it through a helicase enzyme complex ( ...

Scientists interested in DNA replication often study the dynamics of the replication fork (RF), a core structural component of DNA synthesis.

由 JTP Yeeles 著作 · 2013 · 被引用 255 次 — The recovery of stalled replication forks involves fork regression and repriming on the leading strand. In eukaryotes, this occurs in the context of chromatin ...

由 B Michel 著作 · 2004 · 被引用 405 次 — Studies in prokaryotes have provided evidence that inactivated replication forks can restart by the reassembly of the replication machinery. Several strategies ...